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nf-agent @ 0.1.0

Provider: nextflow-io
Claimed: 20 Aug 2026 12:28:34 (UTC)
Description: This Nextflow plugin provides the `langchain4j` agent runner, which integrates language models (OpenAI-compatible APIs) with Nextflow workflows to create AI-powered process primitives that can call external tools and modules. It solves the problem of embedding LLM capabilities directly into data pipelines by executing agents as lightweight Nextflow tasks with full support for retries, parallelism, and lineage tracking. Bioinformaticians and workflow developers would use this to augment their Nextflow pipelines with AI reasoning and decision-making capabilities.
Latest version: 0.1.0
Total downloads: 0 View trends

Summary

This plugin provides the langchain4j agent runner, one of the two runners that execute the Nextflow agent primitive.

An agent is a process-shaped primitive: it declares typed inputs and outputs, renders a prompt, calls a language model — optionally letting the model call Nextflow modules as tools — and emits the result on a channel. Each invocation runs as an ordinary Nextflow task, so work directories, retries, parallelism, resume, and lineage all apply.

The langchain4j runner calls the model from the driver JVM, which makes it the lighter of the two runners: no container is pulled and no runtime is shipped. It speaks the OpenAI wire protocol, so any OpenAI-compatible endpoint can be reached by keeping the openai/ model prefix and pointing agent.baseUrl at it. Agents that need a shell tool or container isolation should use the pi runner (nf-agent-pi) instead.

Agents are a preview feature. Their syntax and behavior may change in future releases.

Get Started

Select the runner in your nextflow.config:

agent.runner = 'langchain4j'

The plugin is loaded automatically when the configuration declares an agent scope. Declare it explicitly to pin a version:

plugins {
    id 'nf-agent@0.1.0'
}

Provide the model credential, either through the environment:

export OPENAI_API_KEY="sk-..."

or through configuration, preferably via a pipeline secret:

agent {
    runner = 'langchain4j'
    apiKey = secrets.LLM_KEY
}

Examples

A single agent

agent qa {
    model 'openai/gpt-5-mini'
    instruction 'You are a concise scientific assistant.'

    input:
    question: String

    output:
    answer: String

    prompt:
    """
    Answer briefly: ${question}
    """
}

workflow {
    qa('What is FASTQ format?').view()
}

Structured output

Declare a record type as the output. It is passed to the model as a JSON schema, and the response is validated against it:

record Classification {
    topic: String
    confidence: Float
}

agent classify {
    model 'openai/gpt-5-mini'

    input:
    text: String

    output:
    result: Classification

    prompt:
    """
    Classify the topic of this abstract: ${text}
    """
}

An OpenAI-compatible endpoint

The openai/ prefix names the wire protocol, not the vendor, so a compatible gateway is reached by setting baseUrl:

agent {
    runner = 'langchain4j'
    baseUrl = 'https://openrouter.ai/api/v1'
    apiKey = secrets.OPENROUTER_KEY
    model = 'openai/gpt-5-mini'
}

Filesystem tools

The model can be given tools, including the built-in filesystem family. On this runner the tools execute in the driver JVM, restricted to the agent's work directory, its staged Path inputs, and the module-output paths returned by module tools; only the work directory is writable:

agent reviewer {
    model 'openai/gpt-5-mini'
    tools 'fs:read', 'fs:grep'

    input:
    report: Path

    output:
    summary: String

    prompt:
    """
    Read ${report} and summarize its findings.
    """
}

License

Apache License 2.0

Nextflow version >=26.08.0-edge
Depends On -
Release Date 20 Aug 2026 12:53:17 (UTC)
Release Notes -
Download URL https://registry.nextflow.io/api/v1/plugins/nf-agent/0.1.0/download/nf-agent-0.1.0.zip
Store URL https://public.cr.seqera.io/v2/nextflow/plugin/nf-agent/blobs/sha256:fc08d58c0828ea9db851443949b35e30be0d75a09b164bd69c82cb8ede839fcb
Size 7.7 MB
Checksum fd4be2258da91e997c625dcb407dddb93fd160df1859c714086bba0c3dcea6b389d425c36cefc9e66809cc28f1925f7a8de3508324aca5a67c5687a7e62114b9
Total downloads 0 View trends
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Version Nextflow version Date Status Downloads
0.1.0 >=26.08.0-edge 20 Aug 2026 12:53:17 (UTC) 0