Description:This Nextflow plugin integrates with Synapse (Sage Bionetworks) to enable transparent reading and writing of files using `syn://` URIs directly within pipelines, supporting versioned files and automatic authentication. It solves the problem of managing biomedical research data stored in Synapse by allowing seamless file access in samplesheets and output publishing. Researchers and bioinformaticians using Nextflow for collaborative biomedical projects would use this plugin to work with Synapse-hosted datasets without manual downloads or custom file handling logic.