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nf-core/demuxem @ 0.0.0-3fc6d40

Demultiplexing cell nucleus hashing data, using the estimated antibody background probability.

Latest version: 0.0.0-6c4ed3a
Total downloads: 9
Source: nf-core/modules

Summary

Demultiplexing cell nucleus hashing data, using the estimated antibody background probability.

Get started

Add the following snippet to your workflow script to include this module.

include { DEMUXEM } from 'nf-core/demuxem'

License

MIT License

Process
Name DEMUXEM
Input 4 channels
#1 tuple
meta map

Groovy Map containing sample information e.g. [ id:'test' ]

input_raw_gene_bc_matrices_h5 string

Path to file containing input raw RNA expression matrix in 10x hdf5 format pattern: "*.{h5}"

input_hto_csv_file string

Path to file containing input HTO (antibody tag) count matrix in CSV format.

*.{csv}
generate_gender_plot string

Generate violin plots using gender-specific genes (e.g. Xist). It is a comma-separated list of gene names.

genome string

Reference genome name. If not provided, the tools infers it from the expression matrix file

generate_diagnostic_plots string

Generate diagnostic plots, including the background/signal between HTO counts, estimated background probabilities, HTO distributions.

Output 3 channels
#1 zarr tuple
meta map

Groovy Map containing sample information e.g. [ id:'sample1' ]

*_demux.zarr.zip file

RNA expression matrix with demultiplexed sample identities in Zarr format.

*_demux.zarr.zip
#2 out_zarr tuple
meta map

Groovy Map containing sample information e.g. [ id:'sample1' ]

*.out.demuxEM.zarr.zip file

DemuxEM-calculated results in Zarr format, containing two datasets, one for HTO and one for RNA.

*.out.demuxEM.zarr.zip
#3 versions_demuxem tuple
${task.process} string

The name of the process

demuxEM string

The name of the tool

demuxEM --version eval

The expression to obtain the version of the tool

Tool Description Homepage
demuxem DemuxEM is the demultiplexing module of Pegasus, which works on cell-hashing and nucleus-hashing genomics data. https://demuxEM.readthedocs.io
Version 0.0.0-3fc6d40
Commit ID 6c4ed3a220310b905a1fc9d04f05be2e0837142b
Release Date 22 Apr 2026 15:10:15 (UTC)
Download URL https://registry.nextflow.io/api/v1/modules/nf-core%2Fdemuxem/0.0.0-3fc6d40/download
OCI Store URL https://public.cr.seqera.io/v2/nextflow/plugin/modules/nf-core/demuxem/blobs/sha256:bdc4e29d693d37908ee331338a8dcbc8f6e29659574033d00bb39f44c2c8f181
Size 3.2 KB
Checksum sha256:bdc4e29d693d37908ee331338a8dcbc8f6e29659574033d00bb39f44c2c8f181
Downloads 3
Version Date Status Downloads Size
0.0.0-6c4ed3a 23 Apr 2026 15:14:03 (UTC) 3 3.2 KB
0.0.0-3fc6d40 22 Apr 2026 15:10:15 (UTC) 3 3.2 KB
0.0.0-0c7146d 08 Apr 2026 18:57:27 (UTC) 3 3.2 KB